| First Author | O'Connor L | Year | 2000 |
| Journal | Cancer Res | Volume | 60 |
| Issue | 5 | Pages | 1217-20 |
| PubMed ID | 10728678 | Mgi Jnum | J:61129 |
| Mgi Id | MGI:1354476 | Citation | O'Connor L, et al. (2000) CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types. Cancer Res 60(5):1217-20 |
| abstractText | The tumor suppressor p53 exerts its antioncogenic effects in cells chiefly by regulating their progression through the cell cycle and by inducing cell death. It has been claimed that p53-transduced apoptosis involves the death receptor CD95 (Fas/APO-1). We report that thymocytes from mice lacking functional Fas ligand (gld) show normal sensitivity to apoptosis transduced by p53, and that hepatocytes fromp53-/- mice have normal sensitivity to apoptosis triggered through ligation of CD95. p53 and CD95, therefore, function in independent pathways to cell death in these diverse cell types. |
