| First Author | Roark JH | Year | 1995 |
| Journal | J Exp Med | Volume | 181 |
| Issue | 3 | Pages | 1157-67 |
| PubMed ID | 7532679 | Mgi Jnum | J:23342 |
| Mgi Id | MGI:71101 | Doi | 10.1084/jem.181.3.1157 |
| Citation | Roark JH, et al. (1995) Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus. J Exp Med 181(3):1157-67 |
| abstractText | Anti-DNA antibodies, specifically those that stain nuclei in a homogeneous nuclear (HN) fashion, are diagnostic of systemic lupus erythematosus (SLE) and the MRL-lpr/lpr SLE murine model. We have used a heavy chain transgene that increases the frequency of anti-HN antibodies to address whether their production in SLE is the consequence of a defect in B cell tolerance. Anti-HN B cells were undetectable in nonautoimmune-prone transgenic mice, but in MRL-lpr/lpr transgenic mice their Ig was evident in the sera and they were readily retrievable as hybridomas. We conclude that nonautoimmune animals actively delete anti-HN-specific B cells, and that MRL-lpr/lpr mice are defective in this process possibly because of the lpr defect in the fas gene. |
