| First Author | Haruwaka K | Year | 2019 |
| Journal | Nat Commun | Volume | 10 |
| Issue | 1 | Pages | 5816 |
| PubMed ID | 31862977 | Mgi Jnum | J:283789 |
| Mgi Id | MGI:6388115 | Doi | 10.1038/s41467-019-13812-z |
| Citation | Haruwaka K, et al. (2019) Dual microglia effects on blood brain barrier permeability induced by systemic inflammation. Nat Commun 10(1):5816 |
| abstractText | Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood-brain barrier (BBB) integrity in this process remains unclear. Using simultaneous in vivo imaging, we demonstrated that systemic inflammation induces CCR5-dependent migration of brain resident microglia to the cerebral vasculature. Vessel-associated microglia initially maintain BBB integrity via expression of the tight-junction protein Claudin-5 and make physical contact with endothelial cells. During sustained inflammation, microglia phagocytose astrocytic end-feet and impair BBB function. Our results show microglia play a dual role in maintaining BBB integrity with implications for elucidating how systemic immune-activation impacts neural functions. |
