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Publication : Depression is an early disease manifestation in lupus-prone MRL/lpr mice.

First Author  Gao HX Year  2009
Journal  J Neuroimmunol Volume  207
Issue  1-2 Pages  45-56
PubMed ID  19121871 Mgi Jnum  J:150619
Mgi Id  MGI:3851078 Doi  10.1016/j.jneuroim.2008.11.009
Citation  Gao HX, et al. (2009) Depression is an early disease manifestation in lupus-prone MRL/lpr mice. J Neuroimmunol 207(1-2):45-56
abstractText  Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.
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