| First Author | Eisenberg RA | Year | 1994 |
| Journal | Semin Immunol | Volume | 6 |
| Issue | 1 | Pages | 49-54 |
| PubMed ID | 8167307 | Mgi Jnum | J:19055 |
| Mgi Id | MGI:67267 | Doi | 10.1006/smim.1994.1008 |
| Citation | Eisenberg RA, et al. (1994) The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice. Semin Immunol 6(1):49-54 |
| abstractText | B cell abnormalities play a central role in the systemic autoimmune syndromes of lpr and gld mice. In the lpr model, autoantibody production requires the intrinsic expression of the lpr gene in B cells, while in the gld mouse the genetic defect is extrinsic, yet probably results in a similar failure of B cell tolerance. Despite their abnormality, lpr B cells require lpr (abnormal) T cells in order to produce autoantibodies. |
