| First Author | Eiche A | Year | 1982 |
| Journal | Hereditas | Volume | 97 |
| Pages | 316-7 (Abstr) | Mgi Jnum | J:28100 |
| Mgi Id | MGI:75732 | Citation | Eiche A, et al. (1982) Dominant or recessive? Different models of expression of a spontaneous new mutation in the mouse. Hereditas 97:316-7 (Abstr) |
| abstractText | Full text of Abstract: 316 ABSTRACTS OF PAPERS. A. EICHE1 and U. HAGLUND2: Dominant or recessive. Different modes of expression of a spontaneous new mutation in the mouse (poster presentation). A spontaneous colour mutation, which occurred in an inbred subline of CS7BL mouse, has been studied from different aspects. The mutation is morphologically dominant but acts as a recessive lethal shortly prior to birth. By appearance and according to preliminary results from test of allelism (J. L. GUENET, personal communication) this is another example of a mutation at the W-locus. The colour of the carriers is grey and white - grey on the head and shoulders and on the haunches. The pattern is distributed in a similar way in all animals. There is no obvious reduction in viability or fertility of intra- and interstrain heterozygotes. When the mutation is transferred to CBA background the homozygotes often survive and are black-eyed, white furred and sterile. About 4 per cent of the intrastrain heterozygotes carry revertant black spots of spontaneous origin. These spots are of varying size and location although they are mostly found in the grey areas. When heterozygous females were subjected to treatment with ethyl methanesulfonate (EMS), on days 8-10 of pregnancy a significant increase in the frequency of young carrying spots was found. This mutant may be useful for genotoxicity studies in the future. 1AB Astra, Toxicology Laboratories, Sodertalje, Sweden 2Department of Medical Cell Genetics, Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden |
