| First Author | Tsujino K | Year | 1998 |
| Journal | Blood | Volume | 91 |
| Issue | 6 | Pages | 2169-74 |
| PubMed ID | 9490705 | Mgi Jnum | J:46739 |
| Mgi Id | MGI:1202017 | Doi | 10.1182/blood.v91.6.2169.2169_2169_2174 |
| Citation | Tsujino K, et al. (1998) Delayed onset of hemolytic anemia in CBA-Pk-1slc/Pk-1slc mice with a point mutation of the gene encoding red blood cell type pyruvate kinase. Blood 91(6):2169-74 |
| abstractText | The Pk-1(slc) gene encodes a mutant red blood cell (RBC) type pyruvate kinase (PK), and adult CBA-Pk-1(slc)/Pk- 1(slc) mice show a severe nonspherocytic hemolytic anemia. However, the number of RBCs and the proportion of reticulocytes were comparable between neonatal CBA-Pk- 1(slc)/Pk-1(slc) mice and control -+/+ mice, Since the age- dependent increase of RBCs was much greater in CBA-+/+ mice than in CBA-Pk-1(slc)/Pk-1(slc) mice, significant anemia was observed in the latter mice on day 14 after birth. The increase of RBCs in CBA-+/+ mice was due to the prolongation of their survival time. The half life of RBCs increased in CBA-+/+ mice with ages, but it decreased in CBA-Pk-1(slc)/Pk-1(slc) mice. The relatively longer half life of RBCs in neonatal CBA-Pk-1(slc)/Pk-1(slc) mice appeared to be due to the delayed switching from M2-type PK that are expressed by undifferentiated erythroid precursor cells to RBC-type PK that are expressed by mature RBCs. (C) 1998 by The American Society of Hematology. |
