| First Author | Sanyal S | Year | 1984 |
| Journal | Exp Eye Res | Volume | 38 |
| Issue | 3 | Pages | 247-56 |
| PubMed ID | 6327341 | Mgi Jnum | J:7447 |
| Mgi Id | MGI:55917 | Doi | 10.1016/0014-4835(84)90163-5 |
| Citation | Sanyal S, et al. (1984) Cyclic nucleotide content and phosphodiesterase activity in the rds mouse (020/A) retina. Exp Eye Res 38(3):247-56 |
| abstractText | Cyclic nucleotide metabolism was examined in the retina and in the retinal pigment epithelium (RPE)-choroid complex of the rds mouse (020/A), a mutant in which discrete photoreceptor outer segment disc structures fail to develop. In retinas of both rds and control (Balb/c) mice, cyclic AMP levels peak at 10-15 days (20-25 pmol mg-1 protein). The level drops to about 10 pmol mg-1 at about one month in normal retinas but remains high in affected retinas. Cyclic GMP levels increase five-fold in Balb/c retinas as ROS develop whereas, in affected retinas, the levels remain constant and low (about 5 pmol mg-1). In RPE-choroid, cyclic nucleotide levels are similar in control and affected mice. Cyclic AMP phosphodiesterase (PDE) activity is somewhat higher in affected than in control retinas; conversely, cyclic GMP-PDE is lower. Both cyclic AMP-PDE and cyclic GMP-PDE activities are different in normal and affected RPE-choroid. Thus, although the rds (020/A) mouse belongs to the early-onset photoreceptor dysplasia group of hereditary retinal degenerations on a morphological basis, it does not exhibit high retinal cyclic GMP levels and thus appears to be distinct from other animals exhibiting early postnatal photoreceptor dysfunction. |
