| First Author | Armstrong C | Year | 2001 |
| Journal | J Comp Neurol | Volume | 439 |
| Issue | 2 | Pages | 151-61 |
| PubMed ID | 11596045 | Mgi Jnum | J:72069 |
| Mgi Id | MGI:2151691 | Doi | 10.1002/cne.1339 |
| Citation | Armstrong C, et al. (2001) Selective Purkinje cell ectopia in the cerebellum of the Weaver mouse. J Comp Neurol 439(2):151-61 |
| abstractText | The adult mouse cerebellar vermis consists of four transverse zones, each of which is further subdivided into parasagittal stripes. In the adult weaver (wv/wv) mouse, the zebrin II expression pattern in the cerebellar vermis is abnormal, consistent with the absence of a central zone ( approximately lobules VI/VII). Because the small, heat shock protein HSP25 is a constitutive marker of parasagittal bands of Purkinje cells in the caudal central zone and the nodular zone ( approximately lobules IX/X), we used HSP25 immunocytochemistry to show that the patterning abnormalities in wv/wv reflect selective Purkinje cell ectopia rather than the absence of the central zone. A specific HSP25-immunopositive Purkinje cell ectopia within the central zone was identified. Symmetrical clusters of HSP25-immunopositive Purkinje cells, which presumably would have formed the parasagittal stripes in the wild type, are present ectopically on either side of the midline in wv/wv. In contrast, in the nodular zone, HSP25-immunopositive Purkinje cells form a near-monolayer and are organized into parasagittal stripes. We therefore conclude that specific Purkinje cell clusters in the wv/wv cerebellum fail to disperse and that this ectopia contributes to the topographical abnormalities. |
