| First Author | Ghetti B | Year | 1991 |
| Journal | J Neurocytol | Volume | 20 |
| Issue | 1 | Pages | 27-38 |
| PubMed ID | 2027034 | Mgi Jnum | J:121260 |
| Mgi Id | MGI:3709695 | Doi | 10.1007/BF01187132 |
| Citation | Ghetti B, et al. (1991) Unique cerebellar phenotype combining granule and Purkinje cell loss: morphological evidence for weaver* pcd double mutant mice. J Neurocytol 20(1):27-38 |
| abstractText | Weaver (wv/wv) mutant mice lose most granule cells of the cerebellum during the first 2 weeks of postnatal life; 'Purkinje cell degeneration' (pcd/pcd) mutants lose virtually all Purkinje cells between postnatal days 17 and 45. Both these neurological mutations are autosomal recessive. We designed a breeding protocol that, in theory, should result in the production of mice with a doubly mutant, wv/wv*pcd/pcd, genotype. Some of the offspring of such crosses had a novel cerebellar phenotype in which both granule and Purkinje cells underwent degeneration, leading to a highly atrophic cortex. This phenotype is what would be expected in wv/wv*pcd/pcd double mutants, and the proportion of such progeny obtained fits with genetic expectations. We propose that (1) wv/wv*pcd/pcd double mutant mice are viable, and (2) the anatomical phenotype of such mice is a combined expression of the component phenotypes. |
