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Publication : Paradoxical increase of tyrosine hydroxylase-immunoreactive retinopetal fibers in the weaver mouse.

First Author  Simon A Year  2000
Journal  Brain Res Dev Brain Res Volume  121
Issue  1 Pages  113-7
PubMed ID  10837899 Mgi Jnum  J:109195
Mgi Id  MGI:3626062 Doi  10.1016/s0165-3806(00)00030-4
Citation  Simon A, et al. (2000) Paradoxical increase of tyrosine hydroxylase-immunoreactive retinopetal fibers in the weaver mouse. Brain Res Dev Brain Res 121(1):113-7
abstractText  Weaver mice undergo apoptosis of the granule cell precursors of the cerebellum and nonapoptotic death of mesencephalic dopaminergic cells during post-natal development. In contrast, the number of retinal dopaminergic cells was transiently increased in weaver compared to control mice [C. Savy, E. Martin-Martinelli, A. Simon, C. Duyckaerts, C. Verney, C. Adelbrecht, R. Raisman-Vozari, J. Nguyen-Legros, Altered development of dopaminergic cells in the retina of weaver mice, J. Comp. Neurol. 1999;412:656-668]. While re-examining the retinas, we observed, in the nerve fiber layer, retinopetal tyrosine hydroxylase-immunoreactive fibers, which were dramatically increased in number throughout development and adulthood in the weaver compared to control mice.
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