| First Author | Shiraishi N | Year | 1993 |
| Journal | Biol Trace Elem Res | Volume | 39 |
| Issue | 2-3 | Pages | 129-37 |
| PubMed ID | 7509170 | Mgi Jnum | J:17081 |
| Mgi Id | MGI:65135 | Doi | 10.1007/BF02783183 |
| Citation | Shiraishi N, et al. (1993) Effect of age and sex on copper-induced toxicity in the macular mutant mouse. An animal model for Menkes' kinky-hair disease. Biol Trace Elem Res 39(2-3):129-37 |
| abstractText | It was determined if the sensitivity in macular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6-8-d-old or 3-4-wk-old macular mutant mouse to copper-induced toxicity was not affected by sex. However, 8-9-wk-old mutant females were more sensitive to copper-induced toxicity than mutant males. Furthermore, 6-8-d-old or 3-4-wk-old mutant males were more sensitive to copper-induced toxicity than 8-9-wk-old mutant males. However, age-related differences in sensitivity to copper-induced toxicity did not occur significantly in mutant females. On the other hand, in the case of normal mice, the sensitivity in 6-8-d-old or 3-4-wk-old mice to copper-induced toxicity was not also affected by sex. In contrast to mutant, however, 8-9-wk-old normal males were more sensitive to copper-induced toxicity than 8-9-wk-old normal females. Adult males were also more sensitive to copper-induced toxicity than 6-8-d-old or 3-4-wk-old males. However, age-related differences in sensitivity to copper-induced toxicity did not occur significantly in normal females. These results indicate that sex- and age-related differences in the copper-induced toxicity exist in macular mutant mice. |
