| First Author | Shiraishi N | Year | 1993 |
| Journal | Biol Trace Elem Res | Volume | 37 |
| Issue | 2-3 | Pages | 179-86 |
| PubMed ID | 7688531 | Mgi Jnum | J:15433 |
| Mgi Id | MGI:63555 | Doi | 10.1007/BF02783793 |
| Citation | Shiraishi N, et al. (1993) Intracellular distribution of hepatic copper in macular mutant mice. An animal model of Menkes' kinky-hair disease. Biol Trace Elem Res 37(2-3):179-86 |
| abstractText | To evaluate the role of lysosomes in copper-mediated hepatocellular injury, copper was administered, sc, to both normal and macular mutant mice at doses of 4.5, 9.0, and 18 mg Cu/kg, and the subcellular distribution of copper has been investigated in the liver of normal and mutant mice 24 h after injection. The amount of copper in all fractions of copper-treated mutant mice was markedly lower than those in copper-treated normal mice, with the exception of microsomal fraction. However, there were no distinct differences in the proportion of copper in subcellular fractions between normal and mutant mice. |
