| First Author | Lu B | Year | 2004 |
| Journal | Brain Res | Volume | 1025 |
| Issue | 1-2 | Pages | 220-5 |
| PubMed ID | 15464763 | Mgi Jnum | J:107774 |
| Mgi Id | MGI:3622007 | Doi | 10.1016/j.brainres.2004.06.081 |
| Citation | Lu B, et al. (2004) Increased c-fos-like immunoreactivity in the superior colliculus and lateral geniculate nucleus of the rd mouse. Brain Res 1025(1-2):220-5 |
| abstractText | In most subcortical visual centers in normal mice maintained for a period in the dark, very few neurons express fos-like immunoreactivity (FLI), most likely reflecting c-fos expression, but if an animal is exposed to a flashing light, there is transient increase in the number of FLI-expressing cells. In dark-maintained retinal degeneration (rd) mice, with an inherited photoreceptor defect, numbers of FLI-positive cells, identified immunohistochemically, are anomalously elevated in the superior colliculus (SC) and lateral geniculate nucleus (LGN). Eye removal largely prevents the elevated counts. The difference in number of FLI-positive cells in the SC of rd mice and nondystrophic controls is highly significant (p<0.001). Because we have previously found a similar phenomenon in Royal College of Surgeons (RCS) rats, in which photoreceptor loss is caused by a retinal pigment cell defect, it argues for an effect related to photoreceptor loss rather than its cause. |
