| First Author | Hopp RM | Year | 1998 |
| Journal | Mol Vis | Volume | 4 |
| Pages | 5 | PubMed ID | 9485488 |
| Mgi Jnum | J:47520 | Mgi Id | MGI:1203709 |
| Citation | Hopp RM, et al. (1998) Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent. Mol Vis 4:5 |
| abstractText | PURPOSE: To determine if p53 mediates apoptosis in photoreceptors of retinal degeneration, rd1, mice. METHODS: The rd1/rd1 mice were interbred with p53 null mice to generate p53-/- rd1/rd1 and p53+/+ rd1/rd1 mice. Rates of loss and incidence of apoptosis in rod photoreceptors were analyzed at appropriate ages (postnatal days 12, 14 and 16). RESULTS: The extent and kinetics of photoreceptor cell loss in rd1 mice were nearly indistinguishable in the p53+/+ and p53 null mice. CONCLUSIONS: Photoreceptor cell apoptosis in the rd1 mouse model occurs by a predominantly p53-independent molecular pathway. |
