| First Author | Bally-Cuif L | Year | 1995 |
| Journal | Mech Dev | Volume | 53 |
| Issue | 1 | Pages | 23-34 |
| PubMed ID | 8555108 | Mgi Jnum | J:29060 |
| Mgi Id | MGI:76584 | Doi | 10.1016/0925-4773(95)00421-1 |
| Citation | Bally-Cuif L, et al. (1995) Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech Dev 53(1):23-34 |
| abstractText | Wnt-1, a putative signaling molecule, is required before the 7 somite stage (E8.5) for the development of midbrain structures in the mouse. We show here that Wnt-1 is also needed for the formation of a boundary between the mesencephalic and metencephalic domains of the neural tube. In embryos homozygous for the Wnt-1sw allele, mesencephalic and metencephalic markers fail to segregate and the establishment of a straight limit of Otx-2 and Wnt-1 expression at the mid-hindbrain junction is impaired. In addition, as observed previously in heterotopic mes/metencephalic transplantation experiments in avian embryos, Wnt-1 expression is induced at the border of ectopic mes- and metencephalic islands observed in Wnt-1sw/sw mutants, suggesting that, in situ, interactions between mes- and metencephalic cells reinforce Wnt-1 expression at the boundary. |
