| First Author | Pandiyan P | Year | 2007 |
| Journal | Nat Immunol | Volume | 8 |
| Issue | 12 | Pages | 1353-62 |
| PubMed ID | 17982458 | Mgi Jnum | J:127761 |
| Mgi Id | MGI:3764784 | Doi | 10.1038/ni1536 |
| Citation | Pandiyan P, et al. (2007) CD4(+)CD25(+)Foxp3(+) regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4(+) T cells. Nat Immunol 8(12):1353-62 |
| abstractText | A key issue in mammalian immunology is how CD4(+)CD25(+)Foxp3(+) regulatory T cells (T(reg) cells) suppress immune responses. Here we show that T(reg) cells induced apoptosis of effector CD4(+) T cells in vitro and in vivo in a mouse model of inflammatory bowel disease. T(reg) cells did not affect the early activation or proliferation of effector CD4(+) T cells. Cytokines that signal through the common gamma-chain suppressed T(reg) cell-induced apoptosis. T(reg) cell-induced effector CD4(+) T cell death required the proapoptotic protein Bim, and effector CD4(+) T cells incubated with T(reg) cells showed less activation of the prosurvival kinase Akt and less phosphorylation of the proapoptotic protein Bad. Thus, cytokine deprivation-induced apoptosis is a prominent mechanism by which T(reg) cells inhibit effector T cell responses. |
