| First Author | Hahne M | Year | 1996 |
| Journal | Eur J Immunol | Volume | 26 |
| Issue | 3 | Pages | 721-4 |
| PubMed ID | 8605944 | Mgi Jnum | J:32020 |
| Mgi Id | MGI:79522 | Doi | 10.1002/eji.1830260332 |
| Citation | Hahne M, et al. (1996) Activated B cells express functional Fas ligand. Eur J Immunol 26(3):721-4 |
| abstractText | Fas ligand (FasL, Apo-1L) is a member of the tumor necrosis factor protein family and binding to its receptor (Fas, Apo-1, CD95) triggers cell death through apoptosis. Ligand expression is restricted to cells with known cytolytic activity and found on hematopoietic cells of the T cell and natural killer lineage. Here we provide evidence that B lymphocytes can express FasL. Flow cytometric analysis revealed that FasL is expressed on the surface of B cells upon stimulation with either lipopolysaccharide or phorbol 12-myristate 13-acetate/ionomycin. FasL expression on activated B cells was confirmed by western blot and reverse transcriptase polymerase chain reaction analysis. FasL on B cells is functional since lipopolysaccharide-activated B lymphocytes derived from wild type, but not from gld mutant mice, were able to kill Fas-sensitive target cells. Our data suggest that the Fas system may contribute to the control of B cell homeostasis. |
