| First Author | Zhao DM | Year | 2006 |
| Journal | Blood | Volume | 107 |
| Issue | 10 | Pages | 3925-32 |
| PubMed ID | 16418326 | Mgi Jnum | J:132735 |
| Mgi Id | MGI:3776736 | Doi | 10.1182/blood-2005-11-4502 |
| Citation | Zhao DM, et al. (2006) Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 107(10):3925-32 |
| abstractText | The suppressive capacity of naturally occurring mouse CD4+CD25+ T cells on T-cell activation has been well documented. The present study is focused on the interaction of CD4+CD25+ T cells and B cells. By coculturing preactivated CD4+CD25+ T cells with B cells in the presence of polyclonal B-cell activators, we found that B-cell proliferation was significantly suppressed. The suppression of B-cell proliferation was due to increased cell death caused by the CD4+CD25+ T cells in a cell-contact-dependent manner. The induction of B-cell death is not mediated by Fas-Fas ligand pathway, but surprisingly, depends on the up-regulation of perforin and granzymes in the CD4+CD25+ T cells. Furthermore, activated CD4+CD25+ T cells preferentially killed antigen-presenting but not bystander B cells. Our results demonstrate that CD4+CD25+ T cells can act directly on B cells and suggest that the prevention of autoimmunity by CD4+CD25+ T cells can be explained, at least in part, by the direct regulation of B-cell function. |
