| First Author | Hayakawa Y | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 1 | Pages | 123-9 |
| PubMed ID | 14688317 | Mgi Jnum | J:87568 |
| Mgi Id | MGI:3027188 | Doi | 10.4049/jimmunol.172.1.123 |
| Citation | Hayakawa Y, et al. (2004) NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy. J Immunol 172(1):123-9 |
| abstractText | Recent studies have implicated a possible role for NK cells in regulating dendritic cells (DC) in vitro. In the present study, we demonstrate that immature DC are rapidly eliminated by NK cells in vivo via a pathway dependent on the TNF-related apoptosis-inducing ligand (TRAIL). Elimination of NK cells and/or neutralization of TRAIL function during immunization with immature DC loaded with nonself or tumor Ags significantly enhanced T cell responses to these Ags and Ag-specific tumor immunity. These data suggested that NK cell TRAIL might regulate responses to vaccination by controlling the survival of Ag-loaded DC. |
