| Primary Identifier | MGI:1856386 | Allele Type | Spontaneous |
| Gene | Cacng2 | Inheritance Mode | Recessive |
| Strain of Origin | MRL/MpJ-Fas<lpr>/J | Is Recombinase | false |
| Is Wild Type | false |
| description | Waggler is a second recessive mutation at the Cacng2 locus that arose in 1988 in the MRL/MpJ-Tnfrsf6 colony maintained at The Jackson Laboratory by Dr. Charles Sidman. Mutant homozygotes are characterized by whole body tremor, an unstable gait, and growth retardation. Hydrocephaly occurs occasionally. Hearing tests by Dr. Lawrence Erway of the University of Cinncinnati showed that the mutant was not deaf. Both sexes breed; no gross neuroanatomical or histopathologic lesions have been found (J:14313). |
| molecularNote | The phenotype of the waggler is associated with aberrant splicing residing in the first intron. Like the stargazer allele, a RT-PCR analysis demonstrated that in addition to aberrant transcripts, some normally spliced mRNA was detected, suggesting that this mutation does not represent a complete null allele. |
