| First Author | Sweet HO | Year | 1991 |
| Journal | Mouse Genome | Volume | 89 |
| Pages | 552-53 | Mgi Jnum | J:14311 |
| Mgi Id | MGI:62482 | Citation | Sweet HO, et al. (1991) Waggler (wag). Mouse Genome 89:552-53 |
| abstractText | Full text of Mouse Genome contribution: Research News: 1. Waggler (wag). Waggler (wag) is a recessive neurological mutation that arose in the MRL/MpJ-lpr colony maintained at The Jackson Laboratory by Dr. Charles Sidman in 1988. It has been mapped to Chromosome 15 near Gpt-1 using the MEV/1Ty linkage testing stock (Cross 1) and a Chr 15 marker stock homozygous for uw - Gpt-1b - Gdc1-1d (Cross 2). The linkage data are summarized in the tables. We believe the order to be cen - uw - Gpt-1- wag - Gdc-1- Ca because in Cross 2 (1) the wag - Gdc-1 distance is less than the Gpt-1 - Gdc-1 distance and (2) Gpt-1 - Gdc-1 recombinational events separated Gpt-1 and wag from Gdc-1 in 9 chromosomes and wag and Gdc-1 from Gpt-1 in 3 chromosomes. The distances between uw - Gpt-1- Gdc-1- Ca are similar to those on the GBASE consensus map and determined by us previously (Davisson et al., Genet. Res. 1990, 56:167). Mutants are characterized by whole body tremor, instability of gait, and growth retardation; they occasionally develop hydrocephaly. Hearing tests by Dr. Lawrence Erway, University of Cincinnati, have shown the mutant is not deaf. It has been placed on the C57BL/6J inbred background to eliminate the effects of the lpr mutation. Both sexes breed. Pathologic studies have revealed no gross neuroanatomical or histopathologic lesions. The mutant will soon be available only from the Frozen Embryo Repository. (Sweet, Bronson, Cook, Spencer, Davisson). Cross 1. MEV/1Ty cross, partial backcross, wag +/+ Ca x wag +/+ +. Progeny: Fl female: ++: 38; wag +: 18; + Ca: 56; wag Ca: 4; Total: 116; RE+/-SE: 19.12 +/- 6.72. Progeny: Fl male: ++: 33; wag +: 23; + Ca: 54; wag Ca: 6; Total: 116; RE+/-SE: 19.43 +/- 6.72. Cross 2. Chr 15 marker stock cross, intercross(a), Fl = uw Gpt-1b + Gdc-1d/+ Gpt-la wag Gdc-lb Progeny Phenotype: uw: uw; Gpt-1: a; wag: wag; Gdc-1: b; Number: 4; RE+/-SE: uw Ð wag = 32.07 +/- 5.33. uw: uw; Gpt-1: ?; wag: wag; Gdc-1: b; Number: 1; RE+/-SE: uw Ð Gpt-1 = 32.14 +/- 4.41. uw: +; Gpt-1: a/b x; wag: wag x; Gdc-1: b/d; Number: 1; RE+/-SE: uw Ð Gdc-1 = 43.75 +/- 4.69. uw: +; Gpt-1: a; wag: wag; Gdc-1: b; Number: 24; RE+/-SE: Gpt-1 = 5.41 +/- 2.63. uw: +; Gpt-1: ab x; wag: wag; Gdc-1: b; Number: 3; RE+/-SE: Gpt-1 Ð Gdc-1 = 17.1 +/- 2.5. uw: +; Gpt-1: a; wag: wag; Gdc-1: bd; Number: 9; RE+/-SE: wag Ð Gdc-1 = 13.51 +/- 3.97. a All mice were scored for uw and wag. Total numbers in phenotypic classes for uw and wag were 98 + +, 55 uw +, 40 + wag, 5 uw wag = 198. |
