| First Author | Fink G | Year | 1982 |
| Journal | J Endocrinol | Volume | 94 |
| Issue | 2 | Pages | 283-7 |
| PubMed ID | 7050282 | Mgi Jnum | J:6840 |
| Mgi Id | MGI:55312 | Doi | 10.1677/joe.0.0940283 |
| Citation | Fink G, et al. (1982) Priming effect of luteinizing hormone releasing hormone in the hypogonadal mouse. J Endocrinol 94(2):283-7 |
| abstractText | We have investigated the LH response to LH releasing hormone (LH-RH) in female hypogonadal (hpg) mice in which the hypothalamus contains no LH-RH and the pituitary gland contains significantly less LH than in normal mice. Both the releasing action and the priming effect of LH-RH were not significantly different in hpg compared with normal mice. Raised plasma concentrations of oestradiol-17 beta reduced pituitary responsiveness to LH-RH in normal but not in hpg mice. These results show that in the mouse neither long-term exposure to normal levels of LH-RH nor a normal pituitary content of LH are necessary for either the releasing or the priming action of LH-RH. |
