| First Author | Tiong J | Year | 2007 |
| Journal | Dev Dyn | Volume | 236 |
| Issue | 11 | Pages | 2980-92 |
| PubMed ID | 17948256 | Mgi Jnum | J:125764 |
| Mgi Id | MGI:3759903 | Doi | 10.1002/dvdy.21332 |
| Citation | Tiong J, et al. (2007) Gonadotropin-releasing hormone-1 (GnRH-1) is involved in tooth maturation and biomineralization. Dev Dyn 236(11):2980-92 |
| abstractText | Gonadotropin releasing-hormone-1 (GnRH-1) is expressed in mouse incisors during development. In this report, we identify (1) cell type(s) that express GnRH-1 throughout tooth development, (2) the GnRH-1 receptor, and (3) the role of GnRH-1/GnRH-1 receptor signaling in tooth maturation. Results show that GnRH-1-positive cells in dental epithelium differentiate and populate multiple tooth structures including ameloblast and papillary layers that are involved in enamel formation and mineralization. The GnRH-1 receptor was present, and in vitro a GnRH-1 antagonist attenuated incisor GnRH-1 cell expression. In vivo, in mice lacking GnRH-1 (-/-), the incisors were discolored, longer, and more curved compared to wildtype. Elemental analysis of calcium, phosphorus, and iron revealed changes in -/- incisors consistent with GnRH-1 affecting movement of minerals into the dental matrix. In sum, in tooth development a signal transduction pathway exists for GnRH-1 via the GnRH-1 receptor and disruption of such signaling affects incisor growth and biomineralization. Developmental Dynamics 236:2980-2992, 2007. Published 2007 Wiley-Liss, Inc. |
