| First Author | Friis-Hansen L | Year | 2000 |
| Journal | Biochem Biophys Res Commun | Volume | 267 |
| Issue | 2 | Pages | 638-42 |
| PubMed ID | 10631115 | Mgi Jnum | J:60206 |
| Mgi Id | MGI:1352971 | Doi | 10.1006/bbrc.1999.2012 |
| Citation | Friis-Hansen L, et al. (2000) Impaired feedback of gastric functions in carboxypeptidase E-deficient mice. Biochem Biophys Res Commun 267(2):638-42 |
| abstractText | Carboxypeptidase E deficiency as seen in the fat/fat mice is associated with reduced antral somatostatin content but tripling of the progastrin product. Thus, fat/fat mice are able to maintain normal tissue concentrations of bioactive alpha-amidated gastrin in spite of grossly attenuated progastrin processing. After induction of achlorhydria, however, neither the amount of alpha-amidated gastrin nor the total progastrin product increased in the fat/fat mice. This is contrary to what is seen in wild-type mice. Furthermore, the synthesis of antral somatostatin and fundic chromogranin A is also abnormal. Hence the results suggest a breakdown in the feedback loop that regulates gastric acid secretion. Copyright 2000 Academic Press. |
