| First Author | Tueting P | Year | 1999 |
| Journal | Neuroreport | Volume | 10 |
| Issue | 6 | Pages | 1329-34 |
| PubMed ID | 10363948 | Mgi Jnum | J:57202 |
| Mgi Id | MGI:1344083 | Doi | 10.1097/00001756-199904260-00032 |
| Citation | Tueting P, et al. (1999) The phenotypic characteristics of heterozygous reeler mouse. Neuroreport 10(6):1329-34 |
| abstractText | Histological and behavioral traits are associated with reelin (Reln) haplo-insufficiency in heterozygous reeler mouse (rl+/-). These phenotypic traits are an approximately 50% decrease of brain Reln mRNA and Reln protein, an accumulation of nicotinamide-adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive neurons in subcortical white matter, an age-dependent decrease in prepulse inhibition of startle (PPI), and neophobic behavior on the elevated plus-maze. Possible analogies between these rl+/- phenotypic traits and signs of psychosis vulnerability are discussed. |
