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Publication : A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex.

First Author  Remedios R Year  2007
Journal  Nat Neurosci Volume  10
Issue  9 Pages  1141-50
PubMed ID  17694053 Mgi Jnum  J:127421
Mgi Id  MGI:3763708 Doi  10.1038/nn1955
Citation  Remedios R, et al. (2007) A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat Neurosci 10(9):1141-50
abstractText  The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link between the amygdala and the neocortex.
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