| First Author | Lutz CM | Year | 1995 |
| Journal | Mouse Genome | Volume | 93 |
| Issue | 3 | Pages | 862 |
| Mgi Jnum | J:29159 | Mgi Id | MGI:76690 |
| Citation | Lutz CM, et al. (1995) Remutation at the waltzer locus. Mouse Genome 93(3):862 |
| abstractText | Full text of Mouse Genome contribution: Research News: 5. Remutation at the waltzer locus. A new neurological mutant was identified in March of 1993, segregating in the B6.C-H2bm1/ByJ foundation stock at The Jackson Laboratory. This mutant, designated nm1971, exhibits frequent vertical head- tossing motions, is ataxic, and shuffles backwards when placed on a smooth surface. Mutant mice are deaf (as tested by auditory brainstem response), with deficiencies in the utricular and saccular otoliths. Breeding studies determined this trait to be inherited as a single autosomal recessive mutation. Initial mapping studies using an F2 intercross with DBA/2J and REVEAL PCR (Kaushik and Stoye, 1994. Mamm Genome 5, 688-95), provided linkage with IAP3rb6 on Chromosome 10. Subsequent mapping in relation to microsatellite markers using MAPMAKER 3.0 for linkage analysis by maximum likelihood, resulted in the following map distance (in cM) and gene order: D10Mit3 - 1.6 - D10Mit40 - 3.3 Ð nm1971 - 4.9 Ð D10Mit20 - 0.0 Ð D10Mit15 - 23.1 - Iap3rb6 - 13.4 Ð D10Mit14. This gene order was favored > 1000:l over the next most likely order. Based on this chromosome location, complementation testing with the mutant waltzer(v) was performed. A +/nm1971 female X +/v male from the V/Le stock yielded 1 female & 2 males affected in a total of 17 progeny. We conclude that nm1971 is a remutation at the waltzer locus and has thus been renamed waltzer-J(vJ). (Cathleen M Lutz, Sue Cook, Roderick T. Bronson, Larry Erway, and Wayne N. Frankel). |
