| First Author | Byrd L | Year | 1991 |
| Journal | Genomics | Volume | 11 |
| Issue | 4 | Pages | 794-8 |
| PubMed ID | 1686018 | Mgi Jnum | J:1534 |
| Mgi Id | MGI:50061 | Doi | 10.1016/0888-7543(91)90002-v |
| Citation | Byrd L, et al. (1991) Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse. Genomics 11(4):794-8 |
| abstractText | Mice with tail kinks and deformities in their lower extremities were observed in a litter of C.D2-Qa-2+N6F15 mice. A mutant line that exhibits this phenotype in 100% of its offspring was established by subsequent breeding. The abnormalities resembled to some degree those found in a human syndrome termed chronic recurrent multifocal osteomyelitis (CRMO). Accordingly, we name the new mutation chronic multifocal osteomyelitis (cmo). Breeding analysis showed that the defect was determined by a single autosomal recessive gene. Restriction fragment length polymorphism (RFLP) analysis of progeny from a backcross between Mus musculus domesticus (CLA) and C.D2-Qa-(2+)-cmo/cmo indicated that the cmo gene resides on mouse Chromosome 18. |
