| First Author | Harris B | Year | 1990 |
| Journal | Mouse Genome | Volume | 86 |
| Pages | 238 | Mgi Jnum | J:14282 |
| Mgi Id | MGI:62453 | Citation | Harris B, et al. (1990) Dorsal dark stripe (dds). Mouse Genome 86:238 |
| abstractText | Full text of Mouse Genome contribution: 5. Dorsal dark stripe (dds). Dorsal dark stripe (dds) is a recessive coat color mutation that arose in the stock carrying the dwarf grey mutation. Homozygous mutants have a dorsal dark stripe and may be of a slightly smaller size than their littermates. Homozygotes of both sexes are viable and fertile, and matings of heterozygotes x homozygotes produce small (3-5 pup) litters. Dorsal dark stripe has been located on Chromosome 15. In a repulsion backcross between the dds stock and RBJ/Dn, a strain carrying 4 Robertsonian chromosomes, linkage with Rb(5.15)3Bnr was detected. Classes of 6 nm Rb, 22 nm +, 22 + Rb and 6 + + gave a recombination estimate of 12/56 = 21.43 +/- 5.48. Linkage with Chr 5 had been previously ruled out on the basis of independent segregation with Pgm-1. A second backcross between the dds stock (Gpt-la Gdc-lb) and an inbred strain derived from Mus castaneus, CAST/Ei Gpt-1b Gdc-ld, was used to position dds on Chr 15. The results of this cross were as follows: Phenotypic classes: dds: dds; Gpt-1: a; Gdc-1: b; No. of Progeny: 29; Recombinants/Total: dds Ð Gpt-1 = 38/152*. dds: +; Gpt-1: ab; Gdc-1: bd; No. of Progeny: 49; Recombinants/Total: dds - Gdc-l = 47/127. dds: dds; Gpt-1: ab; Gdc-1: bd; No. of Progeny: 6; Recombinants/Total: Gpt-1 - Gdc-l = 20/127. dds: +; Gpt-1: a; Gdc-1: b; No. of Progeny: 23. dds: dds; Gpt-1: a; Gdc-1: bd; No. of Progeny:10. dds: +; Gpt-1: ab; Gdc-1: b; No. of Progeny: 8. dds: dds; Gpt-1: ab; Gdc-1: b; No. of Progeny: 0. dds: +; Gpt-1: a; Gdc-1: bd; No. of Progeny: 2. No. of Progeny (Total): l27. * An additional 25 mice were typed only for Gpt-1. These data give recombination estimates and order on Chr 15 of dds - 25.00 +/- 3.51 - Gpt-1 - 15.75 +/- 3.23 - Gdc-1. The mutant phenotype is difficult to classify in outcrosses and the mutation will be available only from frozen embryos. (B. Harris, E.Akeson, C. Spencer, S. Cook, Davisson) |
