| Primary Identifier | MGI:1856694 | Allele Type | Chemically induced (ENU) |
| Gene | Flt4 | Inheritance Mode | Semidominant |
| Strain of Origin | C3H | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The mutation resulting in the Chy phenotype is an A-to-T mutation at position 3157 resulting in an isoleucine to phenylalanine substitution at position 1053 in the tyrosine kinase domain. This mutation is located in a highly conserved catalytic domain of the receptor, in close proximity to the VEGFR-3 mutations in human primary lymphedema. In addition, the Chy mutation was shown to be allelic to an existing targeted mutation in this gene. |
