| First Author | Ueno M | Year | 2014 |
| Journal | Pigment Cell Melanoma Res | Volume | 27 |
| Issue | 4 | Pages | 540-51 |
| PubMed ID | 24730534 | Mgi Jnum | J:289804 |
| Mgi Id | MGI:6430920 | Doi | 10.1111/pcmr.12251 |
| Citation | Ueno M, et al. (2014) Coupling of the radiosensitivity of melanocyte stem cells to their dormancy during the hair cycle. Pigment Cell Melanoma Res 27(4):540-51 |
| abstractText | Current studies have revealed that stem cells are more radiosensitive than mature cells. As somatic stem cells are mostly kept in a quiescent state, this conflicts with Bergonie and Tribondeau's law that actively mitotic cells are the most radiosensitive. In this study, we focused on hair graying to understand the stress-resistance of melanocyte stem cells (McSCs). We used Dct-H2B-GFP transgenic mice which enables the stable visualization of McSCs and an anti-Kit monoclonal antibody which selectively eradicates amplifying McSCs. The results demonstrate that quiescent McSCs are rather radiosensitive, but the coexistence of non-quiescent McSCs provides the stem cell pool with radioresistance. The irradiated quiescent McSCs prematurely differentiate in the niche upon their activation without sufficiently renewing themselves for cyclic hair pigmentation. These data indicate that tissue radiosensitivity is largely dependent on the state of somatic stem cells under their local microenvironment. |
