| First Author | Mullen RJ | Year | 1976 |
| Journal | Proc Natl Acad Sci U S A | Volume | 73 |
| Issue | 1 | Pages | 208-12 |
| PubMed ID | 1061118 | Mgi Jnum | J:5613 |
| Mgi Id | MGI:54090 | Doi | 10.1073/pnas.73.1.208 |
| Citation | Mullen RJ, et al. (1976) Purkinje cell degeneration, a new neurological mutation in the mouse. Proc Natl Acad Sci U S A 73(1):208-12 |
| abstractText | A new autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), is described. Mutants exhibit a moderate ataxia beginning at 3 to 4 weeks of age. The ataxia results from postnatal degeneration of virtually all cerebellar Purkinje cells beginning around 15 to 18 days of age and progressing rapidly over the next 2 weeks. In addition to the cerebellar disease there is slow progressive degeneration in the retina (photoreceptor cells) and olfactory bulb. Also, adult males have abnormal sperm. |
