| First Author | Gavino C | Year | 2011 |
| Journal | Sci Rep | Volume | 1 |
| Pages | 84 | PubMed ID | 22355603 |
| Mgi Jnum | J:206122 | Mgi Id | MGI:5547910 |
| Doi | 10.1038/srep00084 | Citation | Gavino C, et al. (2011) Loss of p53 in quaking viable mice leads to Purkinje cell defects and reduced survival. Sci Rep 1:84 |
| abstractText | The qk(v) mutation is a one megabase deletion resulting in abnormal expression of the qkI gene. qk(v) mice exhibit hypomyelination of the central nervous system and display rapid tremors and seizures as adults. The qkI locus on 6q26-27 has also been implicated as a candidate tumor suppressor gene as the qkI locus maps to a region of genetic instability in Glioblastoma Multiforme (GBM), an aggressive brain tumor of astrocytic lineage. As GBM frequently harbors mutations affecting p53, we crossbred qk(v) and p53 mutant mice to examine whether qk(v) mice on a p53(-/-) background have an increased incidence of GBM. qk(v) (/v); p53(-/-) mice had a reduced survival rate compared to p53(-/-) littermates, and the cause of death of the majority of the mice remains unknown. In addition, immunohistochemistry revealed Purkinje cell degeneration in the cerebellum. These results suggest that p53 and qkI are genetically linked for neuronal maintenance and survival. |
