| First Author | Sumioka A | Year | 2011 |
| Journal | Nat Neurosci | Volume | 14 |
| Issue | 11 | Pages | 1410-2 |
| PubMed ID | 22002768 | Mgi Jnum | J:179775 |
| Mgi Id | MGI:5303036 | Doi | 10.1038/nn.2952 |
| Citation | Sumioka A, et al. (2011) PDZ binding of TARPgamma-8 controls synaptic transmission but not synaptic plasticity. Nat Neurosci 14(11):1410-2 |
| abstractText | The reduction in synaptic transmission and plasticity in mice lacking the hippocampus-enriched AMPA receptor (AMPAR) auxiliary subunit TARPgamma-8 could be a result of a reduction in AMPAR expression or of the direct action of gamma-8. We generated TARPgamma-8Delta4 knock-in mice lacking the C-terminal PDZ ligand. We found that synaptic transmission and AMPARs were reduced in the mutant mice, but extrasynaptic AMPAR expression and long-term potentiation (LTP) were unaltered. Our findings suggest that there are distinct TARP-dependent mechanisms for synaptic transmission and LTP. |
