First Author | Spiegelman M | Year | 1976 |
Journal | J Embryol Exp Morphol | Volume | 36 |
Issue | 2 | Pages | 373-81 |
PubMed ID | 1003077 | Mgi Jnum | J:175675 |
Mgi Id | MGI:5286938 | Doi | 10.1242/dev.36.2.373 |
Citation | Spiegelman M, et al. (1976) Embryological study of a T/t locus mutation (tw73) affecting trophectoderm development. J Embryol Exp Morphol 36(2):373-81 |
abstractText | Mouse embryos homozygous for the recessive lethal mutation tw73 show specific defects in trophectoderm shortly after implantation. The trophectoderm and ectoplacental cone fail to form the usual close association with the uterine decidua, and proliferation is markedly reduced. The embryo proper ceases to develop beyond the two-layered stage and degenerates and dies within 5 days of implantation. |