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Publication : Embryological study of a T/t locus mutation (tw73) affecting trophectoderm development.

First Author  Spiegelman M Year  1976
Journal  J Embryol Exp Morphol Volume  36
Issue  2 Pages  373-81
PubMed ID  1003077 Mgi Jnum  J:175675
Mgi Id  MGI:5286938 Doi  10.1242/dev.36.2.373
Citation  Spiegelman M, et al. (1976) Embryological study of a T/t locus mutation (tw73) affecting trophectoderm development. J Embryol Exp Morphol 36(2):373-81
abstractText  Mouse embryos homozygous for the recessive lethal mutation tw73 show specific defects in trophectoderm shortly after implantation. The trophectoderm and ectoplacental cone fail to form the usual close association with the uterine decidua, and proliferation is markedly reduced. The embryo proper ceases to develop beyond the two-layered stage and degenerates and dies within 5 days of implantation.
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