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Publication : Immunologic tolerance to heterologous immunoglobulin: its relation to in vitro filtration by macrophages.

First Author  Cowing C Year  1977
Journal  J Immunol Volume  119
Issue  1 Pages  256-62
PubMed ID  68973 Mgi Jnum  J:5836
Mgi Id  MGI:54313 Doi  10.4049/jimmunol.119.1.256
Citation  Cowing C, et al. (1977) Immunologic tolerance to heterologous immunoglobulin: its relation to in vitro filtration by macrophages. J Immunol 119(1):256-62
abstractText  The cellular and molecular basis for the difference in ability of BCG to induce tolerance in BALB/c and DBA/2 mice has been examined by in vitro biofiltration. It was found that incubation with the adherent cells from BALB/c but not DBA/2 spleens could remove the material from BGG which inhibited tolerance induction in BALB/c mice. This material was shown to represent only a trace component in BGG, was present in only certain commercial batches of BGG, and was apparently unrelated to the presence of aggregates or endotoxin.
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