| First Author | Gupta A | Year | 2003 |
| Journal | Nat Neurosci | Volume | 6 |
| Issue | 12 | Pages | 1284-91 |
| PubMed ID | 14608361 | Mgi Jnum | J:86637 |
| Mgi Id | MGI:2680890 | Doi | 10.1038/nn1151 |
| Citation | Gupta A, et al. (2003) Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration. Nat Neurosci 6(12):1284-91 |
| abstractText | Several genes essential for neocortical layering have been identified in recent years, but their precise roles in this process remain to be elucidated. Mice deficient in p35-an activator of cyclin-dependent kinase 5 (Cdk5)-are characterized by a neocortex that has inverted layering. To decipher the physiological mechanisms that underlie this defect, we compared time-lapse recordings between p35(-/-) and wild-type cortical slices. In the p35(-/-) neocortex, the classic modes of radial migration-somal translocation and locomotion-were largely replaced by a distinct mode of migration: branched migration. Branched migration is cell-autonomous, associated with impaired neuronal-glial interaction and rare in neurons of scrambler mice, which are deficient in Dab1. Hence, our findings suggest that inside-out layering requires distinct functions of Reelin and p35/Cdk5 signaling, with the latter being important for proper glia-guided migration. |
