| First Author | Haston CK | Year | 2003 |
| Journal | Physiol Genomics | Volume | 12 |
| Issue | 2 | Pages | 79-84 |
| PubMed ID | 12441405 | Mgi Jnum | J:82609 |
| Mgi Id | MGI:2653798 | Doi | 10.1152/physiolgenomics.00114.2002 |
| Citation | Haston CK, et al. (2003) Loci of intestinal distress in cystic fibrosis knockout mice. Physiol Genomics 12(2):79-84 |
| abstractText | The strain-dependent survival of cystic fibrosis (CF) knockout mice has been used to map a modifier of CF, Cfm1, in mice and, subsequently, in humans. To identify additional modifiers of the CF phenotype, in this study, the survival of F2 CF mice derived from a cross between congenic C57BL/6J CF and BALB/cJ CF heterozygotes was followed up to 12 wk of age. A genome-wide linkage scan completed in F2 CF mice revealed a chromosome 10 locus (P = 1.2 x 10(-4)) to predict for intestinal distress in CF male mice. An X chromosome locus for which non-Mendelian inheritance favoring B6 alleles in the surviving CF mice and BALB alleles in mice of a control population, was identified. The survival of female mice, both F2 CF and F2 control, was linked to loci on chromosomes 3 and 5. The identification of additional putative CF modifier loci may permit further genetic dissection of the complex CF phenotype. |
