| First Author | Bauer H | Year | 2007 |
| Journal | Genes Dev | Volume | 21 |
| Issue | 2 | Pages | 143-7 |
| PubMed ID | 17234881 | Mgi Jnum | J:117419 |
| Mgi Id | MGI:3696491 | Doi | 10.1101/gad.414807 |
| Citation | Bauer H, et al. (2007) The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Genes Dev 21(2):143-7 |
| abstractText | Transmission ratio distortion (TRD), the preferential inheritance of the t haplotype from t/+ males, is caused by the cooperative effect of four t-complex distorters (Tcd1-4) and the single t-complex responder (Tcr) on sperm motility. Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region. The t allele of Fgd2 is overexpressed in testis compared with wild type. A loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio of the t haplotype t(h49), directly demonstrating the role of Fgd2 as Distorter. Fgd2 identifies a second Rho G protein signaling pathway promoting TRD. |
