| First Author | Vernet-der Garabedian B | Year | 1998 |
| Journal | Brain Res Mol Brain Res | Volume | 62 |
| Issue | 2 | Pages | 224-7 |
| PubMed ID | 9813341 | Mgi Jnum | J:51056 |
| Mgi Id | MGI:1314535 | Doi | 10.1016/s0169-328x(98)00268-x |
| Citation | Vernet-der Garabedian B, et al. (1998) Abnormal IL-1beta cytokine expression in the cerebellum of the ataxic mutant mice staggerer and lurcher. Brain Res Mol Brain Res 62(2):224-7 |
| abstractText | To assess the extent to which interleukin-1 beta (IL-1 beta) may contribute to the development and/or progression of neurodegenerative processes, we have examined the levels of IL-1 beta in the brain of two types of neurological mutant mice, staggerer and Lurcher. Using a quantitative immunological method (enzyme-linked immunosorbent assay, ELISA), we measured IL-1 beta in the cerebellum, hippocampus and cerebral cortex of mutant mice at baseline and after peripheral LPS treatment. Two types of IL-1 beta expression abnormalities were found in the mutant cerebella: higher basal level in Lurcher and a response to peripheral administration of LPS in staggerer. The association of IL-1 beta expression abnormalities with the only brain structure where a massive neurodegeneration occurs supports the role of proinflammatory cytokines in this process. (C) 1998 Elsevier Science B.V. All rights reserved. |
