| First Author | Halim TY | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 1 | Pages | 57-64 |
| PubMed ID | 26523868 | Mgi Jnum | J:234441 |
| Mgi Id | MGI:5790018 | Doi | 10.1038/ni.3294 |
| Citation | Halim TY, et al. (2016) Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses. Nat Immunol 17(1):57-64 |
| abstractText | Rapid activation of memory CD4(+) T helper 2 (TH2) cells during allergic inflammation requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate lymphoid (ILC2) cells have a crucial role in memory TH2 cell responses, with targeted depletion of ILC2 cells profoundly impairing TH2 cell localization to the lungs and skin of sensitized mice after allergen re-challenge. ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell-attracting chemokine CCL17 by IRF4(+)CD11b(+)CD103(-) dendritic cells (DCs). Consequently, the sentinel function of DCs is contingent on ILC2 cells for the generation of an efficient memory TH2 cell response. These results elucidate a key innate mechanism in the regulation of the immune memory response to allergens. |
