| First Author | Webster DB | Year | 1986 |
| Journal | Acta Otolaryngol | Volume | 101 |
| Issue | 5-6 | Pages | 429-38 |
| PubMed ID | 3727977 | Mgi Jnum | J:94384 |
| Mgi Id | MGI:3512690 | Doi | 10.3109/00016488609108628 |
| Citation | Webster DB, et al. (1986) Incomplete maturation of brainstem auditory nuclei in genetically induced early postnatal cochlear degeneration. Acta Otolaryngol 101(5-6):429-38 |
| abstractText | In the Shaker-2 mouse mutant, a cochleo-saccular type of genetically induced inner ear degeneration occurs. Morphological signs of degeneration are evident in the 3rd postnatal week and a severe and almost total degeneration has occurred by the age of 6-9 weeks. There are no qualitative differences between the brain of the normal CBA/J mouse and that of the Shaker-2 mouse. The growth of the auditory brainstem nuclei (dorsal cochlear nucleus and ventral cochlear nucleus) in the mutant Sh-2 mouse has stopped by 14 days of age--but not in the normal CBA/J mouse. The brainstem as a whole continues to grow between 14 and 140 days of age in both strains. The early cochlear degeneration coincides with the critical period when a normal input from the peripheral receptor organ is necessary for the maturation of the central auditory pathway. |
