| First Author | Ruthig VA | Year | 2017 |
| Journal | Biol Reprod | Volume | 96 |
| Issue | 3 | Pages | 694-706 |
| PubMed ID | 28339606 | Mgi Jnum | J:244947 |
| Mgi Id | MGI:5913726 | Doi | 10.1095/biolreprod.116.144006 |
| Citation | Ruthig VA, et al. (2017) Testicular abnormalities in mice with Y chromosome deficiencies. Biol Reprod 96(3):694-706 |
| abstractText | We recently investigated mice with Y chromosome gene contribution limited to two, one, or no Y chromosome genes in respect to their ability to produce haploid round spermatids and live offspring following round spermatid injection. Here we explored the normalcy of germ cells and Sertoli cells within seminiferous tubules, and the interstitial tissue of the testis in these mice. We performed quantitative analysis of spermatogenesis and interstitial tissue on Periodic acid-Schiff and hematoxylin-stained mouse testis sections. The seminiferous epithelium of mice with limited Y gene contribution contained various cellular abnormalities, the total number of which was higher than in the males with an intact Y chromosome. The distribution of specific abnormality types varied among tested genotypes. The males with limited Y genes also had an increased population of testicular macrophages and internal vasculature structures. The data indicate that Y chromosome gene deficiencies in mice are associated with cellular abnormalities of the seminiferous epithelium and some changes within the testicular interstitium. |
