| First Author | Sampson HW | Year | 1988 |
| Journal | Am J Anat | Volume | 182 |
| Issue | 3 | Pages | 257-69 |
| PubMed ID | 3213824 | Mgi Jnum | J:109941 |
| Mgi Id | MGI:3630117 | Doi | 10.1002/aja.1001820307 |
| Citation | Sampson HW (1988) Ultrastructure of the mineralizing metacarpophalangeal joint of progressive ankylosis (ank/ank) mice. Am J Anat 182(3):257-69 |
| abstractText | The metacarpophalangeal joint of the progressive ankylosis mouse was examined at 4, 6 and 8 weeks of age by using electron microscopy and electron probe microanalysis. These studies describe the progression of the disorder, and they reveal three overlapping phases: pannus proliferation, chondrophyte formation and mineralization, and articular cartilage mineralization. The chondrophyte mineralized in a manner fairly similar to endochondrial bone, whereas articular cartilage mineralized by advancement of a calcification front across the cartilage. Synovial crystal phagocytosis was also observed. The progressive ankylosis mouse should be an important model for studying both crystal deposition and abnormal articular cartilage calcification. |
