| First Author | Johansen JE | Year | 2001 |
| Journal | Neuroreport | Volume | 12 |
| Issue | 12 | Pages | 2737-41 |
| PubMed ID | 11522958 | Mgi Jnum | J:103710 |
| Mgi Id | MGI:3610641 | Doi | 10.1097/00001756-200108280-00029 |
| Citation | Johansen JE, et al. (2001) Altered dopaminergic transmission in the anorexic anx/anx mouse striatum. Neuroreport 12(12):2737-41 |
| abstractText | We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype. |
