| First Author | Lachuer J | Year | 2005 |
| Journal | Brain Res Mol Brain Res | Volume | 139 |
| Issue | 2 | Pages | 372-6 |
| PubMed ID | 16006007 | Mgi Jnum | J:103396 |
| Mgi Id | MGI:3609427 | Doi | 10.1016/j.molbrainres.2005.06.003 |
| Citation | Lachuer J, et al. (2005) Gene expression profiling reveals an inflammatory process in the anx/anx mutant mice. Brain Res Mol Brain Res 139(2):372-6 |
| abstractText | Anorexia (anx) is a recessive mutation that causes lethal starvation in homozygous mice. Studies of anx/anx mice hypothalamus have shown abnormalities in the orexigenic (NPY/AGRP neurons) and the anorexigenic (POMC/CART neurons) pathways. By gene expression profiling using cDNA and oligonucleotide microarrays, we have shown that a surexpression of genes involved in inflammatory process occurred in anx mice hypothalamus. This inflammatory process could be the cause of the anorexia phenotype observed in these mice. |
