| First Author | Beamer WG | Year | 1984 |
| Journal | Mouse News Lett | Volume | 70 |
| Pages | 84 | Mgi Jnum | J:35669 |
| Mgi Id | MGI:83117 | Citation | Beamer WG, et al. (1984) Juvenile spermatogonal depletion (jsd). Mouse News Lett 70:84 |
| abstractText | Full text of MNL contribution: 2. Juvenile spermatogonal depletion (jsd). A new mutation affecting male fertility has been recovered from the Jackson Laboratory's Animal Resources colonies. Affected males were characterized by hypoplastic testicles, normal serum testosterone, elevated serum follicle stimulating hormone, azospermia, and normal body and seminal vesicle weights. Systematic histological examination of testes from affected and normal males between 3 and 52 weeks of age provided an insight into the cause of the male sterility and a basis for naming this mutation. At 3-4 weeks of age, a variable number of testicular tubules contained a reduced complement of spermatogenic cells. By 5-7 weeks of age, some tubules contained mature spermatozoa; but, other tubules were deficient in all stages of spermatogenesis. By 8 - 10 weeks of age, most, if not all tubules, were devoid of spermatogenic cells, leaving only Sertoli cells. In view of these observations, this new mutation has been named juvenile spermatogonal depletion (jsd). Parents of jsd/jsd male mice were outcrossed to C3H/HeJ mice. None of the resultant B6C3F>1< or C3B6F>1< male mice had hypoplastic testicles or ovaries. In the C3B6F>2< generation, 68 males with hypoplastic testicles and 202 males with normal testicles were observed, Matings between C3B6F>1< female mice, jsd/+ and sires of jsd/jsd male mice produced 22 males with hypoplastic testicles and 66 males with normal testicles. These data indicate a single gene autosomal recessive mode of inheritance. Reproducttve data indicated that jsd/jsd female mice were fertile and could be identified only by test mating tojsd/+ males. (Beamer, T. C. Beamer and K. Shultz) |
