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Publication : Proto-oncogene c-jun and c-fos messenger RNAs increase in the liver of carnitine-deficient juvenile visceral steatosis (jvs) mice.

First Author  Tomomura M Year  1992
Journal  FEBS Lett Volume  311
Issue  1 Pages  63-6
PubMed ID  1383034 Mgi Jnum  J:2818
Mgi Id  MGI:51339 Doi  10.1016/0014-5793(92)81368-v
Citation  Tomomura M, et al. (1992) Proto-oncogene c-jun and c-fos messenger RNAs increase in the liver of carnitine-deficient juvenile visceral steatosis (jvs) mice. FEBS Lett 311(1):63-6
abstractText  We determined the mRNA levels of c-jun and c-fos in the liver of C3H-H-2 degrees jvs mice. Both were higher in jvs mice than in normal mice. The level of c-jun mRNA increased gradually after birth, but in the control mice there was almost no change. In addition, alpha-fetoprotein and aldolase A mRNA levels were also higher than in normal littermates. These results suggest that the pattern of the gene expression in jvs mice partly resembles the one that occurs in undifferentiated hepatocytes and/or hepatocellular carcinoma.
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