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Publication : Deficiency in the thymus-dependent immunity in "lethargic" mutant mice.

First Author  Dung HC Year  1977
Journal  Transplantation Volume  23
Issue  1 Pages  39-43
PubMed ID  13525 Mgi Jnum  J:5766
Mgi Id  MGI:54243 Doi  10.1097/00007890-197701000-00007
Citation  Dung HC (1977) Deficiency in the thymus-dependent immunity in lethargic mutant mice. Transplantation 23(1):39-43
abstractText  T cell function of lethargic mutant mice which exhibit spontaneous thymic involution was evaluated by skin transplantation and graft-versus-host reaction tests. At 15 to 30 days of age, the mutant mice did not reject skin allografts, but by 45 days of age their response was normal. Spleen cells from 24-day-old mutant donors demonstrated delayed appearance of graft-versus-host induced splenomegaly in F1 recipients. Implications of these results in understanding the immunological status of lethargic mice were considered.
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